AP traces and algesic response profile for sub-classes of CGRP-cre⁺ DRG neurons.

<p>For each CGRP-cre⁺ sensory neuronal group recorded from mouse DRG, the AP, response to ATP (30μM), capsaicin (100nM; CAP), 5-HT (30μM) and mustard oil (10μM; MO) are presented from left to right. The AP time scale (horizontal bar) is 5 msec for each panel. I_ATP time scale is 1 sec for each panel. I_ATP magnitude (vertical bar) scales are indicated for each panel. Name of the groups are also indicated when two I_ATP traces are presented on a panel. I_CAP time scale is 10 sec for each panel. I_CAP magnitude scale is indicated. I_5-HT was recorded from S3, but not S2 neurons. I_5-HT time and magnitude scales are 1 sec and 50 pA, respectively, for each panel. An exception is the M1/M1a group that has a large I_5-HT current. MO responses were measured by Ca²⁺ imaging. CGRP-cre⁺ sensory neuronal groups are shown for each row. Drug application times are illustrated by horizontal bar above traces. More complete information on subgroups is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198601#pone.0198601.t002" target="_blank">Table 2</a>.