MAPK-15 localizes to dendrite endings and requires its kinase activity and LIR motif.

<p>(A) Wild-type L4 animal expressing <i>flp-8</i>pro:mCherry (URX) and <i>flp-8</i>pro:superfolderGFP-MAPK-15 (URX). Arrow, dendrite ending. (B) Relative enrichment of superfolderGFP-MAPK-15 at the dendrite ending compared to its middle, as shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007435#pgen.1007435.s006" target="_blank">S4 Fig</a>. Mean enrichment ± SD, 3.7 ± 2.0. n = 20. (C) Wild-type or <i>mapk-15</i> animals bearing no transgene (–) or a transgene encoding wild-type, kinase-dead (K42A), or ΔLIR alleles of <i>mapk-15</i> under its own promoter were synchronized as two-day adults and dendrite and nose lengths were measured. Colored bars, individual animals; black bars, population averages. n = 50 in all cases.