Additional file 7: of Targeting tumour re-wiring by triple blockade of mTORC1, epidermal growth factor, and oestrogen receptor signalling pathways in endocrine-resistant breast cancer
- Ricardo Ribas (222948)
- Sunil Pancholi (222942)
- Aradhana Rani (529007)
- Eugene Schuster (12754)
- Stephanie Guest (5350772)
- Joanna Nikitorowicz-Buniak (776212)
- Nikiana Simigdala (424363)
- Allan Thornhill (5350766)
- Francesca Avogadri-Connors (5350769)
- Richard Cutler (5350763)
- Alshad Lalani (5350775)
- Mitch Dowsett (645)
- Stephen Johnston (767275)
- Lesley-Ann Martin (222958)
Publication date
June 2018
DOIAbstract
Figure S7. Assessment of dynamic changes in expression of cell cycle regulatory genes. (a) Log2 differences in CCNE1, CCNL1, CDK3, CDK7, and CDK9 gene expression following treatment with RAD001, RAD001 + neratinib, and RAD001 + neratinib + fulvestrant (ICI), compared with vehicle. (b) GSEA enrichment plots for 198 genes known to be induced by sustained activation of ERK in response to EGF activity. Plots show the profile of the running Enrichment Score and positions of GeneSet Members on the Rank Ordered List for rank gene lists generated from the comparison of: ICI vs. vehicle; neratinib + ICI vs. ICI; RAD001 + ICI vs. ICI; and RAD001 + neratinib + ICI vs. RAD001 + ICI. (PDF 721 kb
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