Identification of transchromosomal interactions in mammalian immune cells.

<p><b>(A)</b> Promoter capture HiC contact matrix in human CD4⁺ T cells confirming intrachromosomal interactions previously reported in the mouse Th2 locus control region <b>(B)</b> Heatmaps of chromosomes involved in detected transchromosomal interactions in mouse B cells, CD4⁺ and CD8⁺ T cells before and after exclusion of interactions associated with blacklisted regions. <b>(C)</b> Numbers of transchromosomal (upper panels) and intrachromosomal interactions (lower panels) common, or unique to murine B cells, CD4⁺ or CD8⁺ T cells before (white) and after (black) exclusion of interactions associated with blacklisted regions. <b>(D)</b> Circos plot of transchromosomal interactions in human B cells. Insets show examples of interactions associated with centromeres and telomeres. Centromeres are shown in red. <b>(E)</b> Association of mouse or human B cell specific transchromosomal (black histogram) and intrachromosomal interactions (grey line) with telomeres or centromeres. The x-axis is normalised to chromosome length starting from the telomere.