Effects of oxaliplatin treatment on cytokine and chemokine mRNA expression.

<p>To determine whether oxaliplatin treatment induced changes in inflammatory mediators within the colon, RT² Profiler PCR arrays were performed using pooled RNA samples from (vehicle, n = 5; oxaliplatin, n = 4) samples. Oxaliplatin treatment caused the down-regulation of the cytokines IL-1β, IL-12β mRNA expression when compared to the vehicle-treated group <b>(A)</b>. Oxaliplatin treatment induced the up-regulation of the chemokine Ccl2, and the down-regulation of Ccl5 and Ccl22 chemokine mRNA expression when compared to the vehicle-treated cohort <b>(B)</b>.