The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life - Fig 4

<p>A. Expression of target genes from the three branches of UPR (IRE1 alpha, ATF6 and PERK) at PND105. Values are expressed as fold change (mean + SD, ** p<0.005). B. WIB of UPR activation (IRE1 alpha, ATF6 and PERK) at PND105. C. Relationship between mRNA Xbp1s and pAkt protein level (r = 0.86, p < 0.002) in IUGR animals. D. Relationship between liver fibrosis score (F1 and F2) and mRNA levels of UPR (IRE1 alpha and PERK), *p<0.05.