Hepatic injury regulated by T cells during rodent malaria.

<p>(a) Kinetics of pRBC rate in peripheral blood after infection of 10⁶ pRBCs in <i>nu/nu</i> mice and WT mice (n = 5). (b) Hematocrit in <i>nu/nu</i> mice and WT mice after Pb-infection (n = 5). (c) The body weight change of <i>nu/nu</i> mice and WT mice after Pb-infection (n = 5). (d) Serum concentration of AST (left) and ALT (right) of <i>nu/nu</i> mice and WT mice after Pb-infection (n = 5). (e) mRNA expression of iNOS (left) and IFN-γ (right) in the liver of <i>nu/nu</i> mice and WT mice treated with LPS (n = 5). (f) IFN-γ produced by Pb-pRBC antigen-specific T cells. Splenocytes (5 x 10⁶ cells/ml) of Pb-infected mice or naïve mice were stimulated by Pb-pRBC (1 x 10⁸ cells/ml), nRBC (1 x 10⁸ cells/ml) or conA (3 µg/ml) and the concentration of IFN-γ secreted in supernatant was measured by ELISA. Graphs show mean and SD of each group. Data are representative of two independent experiments. ^*<i>P</i> < 0.05; n.s., not significant.