Exacerbation of hepatic injury by rMRP14 during rodent malaria.

<p>(a) Histopathology of the liver of mice injected with rMRP14 or PBS after Pb-infection analyzed by HE staining. The area surrounded by dotted line shows focal necrosis. Bar; 50 µm. (b)(c) Serum concentration of AST (b) and ALT (c) of mice injected with rMRP14 or PBS after Pb-infection (n = 5). (d) No effect of rMRP14 on parasite proliferation. Kinetics of pRBC rate in peripheral blood after infection of 10⁶ pRBCs in rMRP14-injected mice and PBS-injected controls (n = 5). (e) The body weight change of mice injected with rMRP14 or PBS after Pb-infection (n = 5). Graphs show mean and SD of each group. Data are representative of two independent experiments. ^*<i>P</i> < 0.05; n.s., not significant.