The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia - Fig 4

<p>(A) Average neutralising antibody titres of the vaccinated (VC) and unvaccinated (UC) contact sheep to the vaccine virus (A22 Iraq) and the challenge virus (A/VIT/2012). Values represent Log₁₀ of the reciprocal of the highest dilution of serum that was able to neutralise either A22 Iraq or A/VIT/2012. The assay cut off was 0.9, titres ≥1.2 are considered positive. Error bars show standard deviation. Time to seroconversion plots estimated by the Kaplan-Meier method for the vaccinated and non-vaccinated in-contact sheep (B) for the ELISA to the structural protein; and (C) for the ELISA to the non-structural protein. Note that for both groups of sheep, the start time for the estimate is when the sheep entered the room housing the donors, and not the day that the vaccine was administered.