Effect of CPA treatment on ERG recordings (I): a-wave and b-wave.

<p>A) Basal ERG response of a CPA treated eye. B) ERG response a week after CI of a CPA treated eye. Observe a small increase of a-wave amplitude and the preservation of b-wave amplitude compared to Basal ERG (A). C) Basal ERG response of CTL eye. D) ERG response a week after CI of a CTL eye. Observe a decrease of both a-wave amplitude and b-wave amplitudes. E) Quantification of a-wave amplitude of both eyes a week after injection and 1d of CI. A significant higher amplitude of of a-wave was detected in CPA treated eyes compared to CTL eyes (14.07 ± 3.56 μV vs 7.14 ± O.63, unpaired Student´s t-test; p<0.05; n = 5), *p< 0.05. F) Quantification of b-wave amplitude of both eyes a week after injection and 1d of CI. A significant higher amplitude of b-wave was detected between CPA treated eyes compared to CTL eyes (106 ± 57.9 μV vs 60.11 ± 37.37 µV; unpaired Student´s t-test; p<0.05; n = 5), *p< 0.05.