<p><b>A.</b> The size probability distribution for an established clone multiple years after diagnosis (20%). Being a one hump function, the distribution is asymmetric, stretching further to the right (larger sizes, see main text for details). <b>B.</b> Probabilities for an established clone to recede or vanish after diagnosis (20%) over time.</p
Background: A growing population of cells accumulates mutations. A single mutation early in the grow...
<p>The expected frequency of mutants according to geometric distribution is shown in bold italics.</...
In this paper we study the fate of a gene that has just been introduced into a large population that...
<p><b>A.</b> Likelihood of existence of clones over time. As a test of accuracy, the probabilities f...
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemo...
<div><p>Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized...
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemo...
The pool of hematopoietic stem cells that actively contributes to hematopoiesis is small, and the ce...
<p><b>A.</b> The probability of clinical PNH occurring in an individual between the ages of 1–100 ye...
<p>The left part of the distribution remains unchanged, while the right tail gets closer to a unifor...
<p>(A) New passenger mutations can be lost due to stochastic drift (diamonds). Successful mutations ...
Several human genetic diseases are associated with inheriting an abnormally large unstable DNA simpl...
In this study, we aimed at disclosing the main features of paroxysmal nocturnal hemoglobinuria (PNH)...
Several human genetic diseases are associated with inheriting an abnormally large unstable DNA simpl...
<p>The left part of the distribution remains unchanged, while the right tail gets closer to a unifor...
Background: A growing population of cells accumulates mutations. A single mutation early in the grow...
<p>The expected frequency of mutants according to geometric distribution is shown in bold italics.</...
In this paper we study the fate of a gene that has just been introduced into a large population that...
<p><b>A.</b> Likelihood of existence of clones over time. As a test of accuracy, the probabilities f...
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemo...
<div><p>Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized...
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemo...
The pool of hematopoietic stem cells that actively contributes to hematopoiesis is small, and the ce...
<p><b>A.</b> The probability of clinical PNH occurring in an individual between the ages of 1–100 ye...
<p>The left part of the distribution remains unchanged, while the right tail gets closer to a unifor...
<p>(A) New passenger mutations can be lost due to stochastic drift (diamonds). Successful mutations ...
Several human genetic diseases are associated with inheriting an abnormally large unstable DNA simpl...
In this study, we aimed at disclosing the main features of paroxysmal nocturnal hemoglobinuria (PNH)...
Several human genetic diseases are associated with inheriting an abnormally large unstable DNA simpl...
<p>The left part of the distribution remains unchanged, while the right tail gets closer to a unifor...
Background: A growing population of cells accumulates mutations. A single mutation early in the grow...
<p>The expected frequency of mutants according to geometric distribution is shown in bold italics.</...
In this paper we study the fate of a gene that has just been introduced into a large population that...