<p>The frequencies of Mamu-A*01/Gag CM9 and Mamu-A*01/Tat SL8 tetramer+ CD8+ T-cells in PBMC at week 10 post rRRV-SIVcmv-nfl inoculation are shown in the left panels for r11089 (A) and r11099 (B). The middle panels show the delineation of memory subsets within the tetramer+ gate based on the differential expression of CD28 and CCR7. Three subsets were identified: central memory (T<sub>CM</sub>; CD28+CCR7+), transitional memory (T<sub>EM1</sub>; CD28+CCR7-), and effector memory (T<sub>EM2</sub>; CD28-CCR7-). The histograms in the right panels show the levels of granzyme B expressed by tetramer+ CD8+ T-cells (blue lines). The red lines correspond to tetramer+ CD8+ T-cells stained with an isotype-matched control monoclonal antibody.</p
T cell "memory inflation" is the sustained induction of effector memory cells that home to periphera...
The main functions of memory T cells are to provide protection upon re-exposure to a pathogen and to...
CMVs are beta herpesviruses that establish lifelong latent infection of their hosts. Acute infection...
(A) Boxplots comparing the memory differentiation of the RhCMV/PK4 or ΔRh186-9/PK4-elicited CD4+ and...
Infection with murine cytomegalovirus (MCMV) induces a large population of virus-specific CD8+ T-cel...
Memory differentiation state was based on CD45RO versus CCR7 expression to distinguish between naïve...
Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A re...
<p>Frozen and thawed PBMCs from 6 months (6m), and 1 (1y) and 2 (2y) years after the last vaccine ad...
Effective secondary response to antigen is a hallmark of immunological memory. However, the extent o...
<p>For six HLA-A*02:01-positive vaccine recipients, frozen and thawed PBMCs from indicated time poin...
Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a mo...
CD8(+) T cell memory inflation, first described in murine CMV (MCMV) infection, is characterized by ...
<p>(A) In C57BL/6 mice infected with K181 MCMV, M38-specific T cells accumulate over time while M45-...
In order to elicit the ideal set of memory CD8 T cells, rational vaccine design and planning for vac...
The generation of CD8(+) T-cell memory is a major aim of vaccination. While distinct subsets of CD8(...
T cell "memory inflation" is the sustained induction of effector memory cells that home to periphera...
The main functions of memory T cells are to provide protection upon re-exposure to a pathogen and to...
CMVs are beta herpesviruses that establish lifelong latent infection of their hosts. Acute infection...
(A) Boxplots comparing the memory differentiation of the RhCMV/PK4 or ΔRh186-9/PK4-elicited CD4+ and...
Infection with murine cytomegalovirus (MCMV) induces a large population of virus-specific CD8+ T-cel...
Memory differentiation state was based on CD45RO versus CCR7 expression to distinguish between naïve...
Summary: The induction and maintenance of T cell memory is critical to the success of vaccines. A re...
<p>Frozen and thawed PBMCs from 6 months (6m), and 1 (1y) and 2 (2y) years after the last vaccine ad...
Effective secondary response to antigen is a hallmark of immunological memory. However, the extent o...
<p>For six HLA-A*02:01-positive vaccine recipients, frozen and thawed PBMCs from indicated time poin...
Longitudinal studies on the kinetics of viral antigen specific CD8 T cell responses have led to a mo...
CD8(+) T cell memory inflation, first described in murine CMV (MCMV) infection, is characterized by ...
<p>(A) In C57BL/6 mice infected with K181 MCMV, M38-specific T cells accumulate over time while M45-...
In order to elicit the ideal set of memory CD8 T cells, rational vaccine design and planning for vac...
The generation of CD8(+) T-cell memory is a major aim of vaccination. While distinct subsets of CD8(...
T cell "memory inflation" is the sustained induction of effector memory cells that home to periphera...
The main functions of memory T cells are to provide protection upon re-exposure to a pathogen and to...
CMVs are beta herpesviruses that establish lifelong latent infection of their hosts. Acute infection...