SRPX2 KO mice show a reduction of VGlut2 synapse density in layer IV of the SS cortex.

<p>Immunostaining of SS cortex layer IV for (A) excitatory presynaptic marker VGlut1 (red) and postsynaptic marker PSD95 (green), (B) excitatory presynaptic marker VGlut2 (red) and PSD95 (green), and (C) inhibitory presynaptic marker VGAT (red) and postsynaptic marker gephyrin (green). Synapses are composed of colocalized presynaptic and postsynaptic markers, indicated by circles. Scale bar 5 μm (A-C). Analyzed with Student’s t-test, two-tailed. n = 3–4 mice per group, 3–4 optical stacks per mouse. All data plotted as mean ± S.E.M. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001.