ARQ-197 inhibits bone formation loss on the cortico-endosteal surface of the tibiae from JJN3 tumour-bearing mice.

<p>Representative images of bone formation on the, cortico-endosteal surfaces, <b>(A)</b> magnification x4 (scale bar = 500 μm) and <b>(B)</b> magnification x20 (scale bar = 100 μm) of tibiae from naïve mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). Histomorphometric analysis of <b>(C)</b> the mineralising surface (MS, %) <b>(D)</b> the mineral apposition rate (MAR, μm/day) and <b>(E)</b> the bone formation rate (BFR/BS, mm² X 10⁻³/mm/day) on the cortico-endosteal bone surface of tibiae from naive mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). All data displayed as mean ± SD and analysed using a normal one-way ANOVA, where significance is indicated by *P<0.05, ***P<0.001 or ****P<0.0001.