PTPD reduces HBV replication in HBV infection models.
- Kouichi Kitamura (407158)
- Lusheng Que (5434616)
- Miyuki Shimadu (716824)
- Miki Koura (413181)
- Yuuki Ishihara (2218771)
- Kousho Wakae (716823)
- Takashi Nakamura (8496)
- Koichi Watashi (222543)
- Takaji Wakita (109321)
- Masamichi Muramatsu (407159)
Publication date
June 2018
DOIAbstract
<p>(A) HepG2-hNTCP-C4 cells were pretreated with PTPD (5 μM) for 1 day, and subsequently infected with HBV in PTPD-containing culture medium. cccDNA levels at 3 dpi were analyzed by Southern blotting. (B) PXB cells (primary human hepatocytes) were pretreated with PTPD (5 μM) or 3TC (50 μM) from 1 day before infection to 7 dpi. Secreted HBV DNA levels were quantified at the indicated time points (left side). HBV RNA was quantified by RT-qPCR at 21 dpi (right side). Asterisks indicate statistically significant differences; *<i>P</i> < 0.05 compared with DMSO.</p
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