Analysis of a conditional gene trap reveals that <i>tbx5a</i> is required for heart regeneration in zebrafish - Fig 2

<p><b><i>tbx5a</i>^<i>tpl58</i> mutant phenotypes. A-D.</b> Larvae heterozygous for <i>tbx5a</i>^<i>tpl58</i> gene trap allele display severe but variable fin defects at 5 days post fertilization. Compared to wild type siblings (a), heterozygous mutants display bilaterally equal fin truncation (b), or unequal fin truncation with left (c) or right (d) pectoral fin more severely affected. <b>E.</b> Gene trap homozygotes display a phenotype similar to the more severe version of <i>heartstrings</i> phenotype described previously (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0197293#pone.0197293.g001" target="_blank">Fig 1D and 1E</a> in Garrity <i>et al</i>., 2002). <b>F-H.</b> All adults heterozygous for the gene trap had hearts with enlarged atria and mis-shapen (blunt) ventricles (n = 13). <i>a</i>, atrium, <i>v</i>, ventricle, <i>ba</i>, <i>bulbus arteriosus</i>.