TNBS colitis reduces body weight, shortens colon length, damages epithelial barrier integrity and increases colonic IL-1β.

<p>A) Body weight was significantly reduced 24 and 48 hours following TNBS treatment relative to healthy controls (▲ Healthy, ● TNBS, N = 10). B) Colon length was significantly shortened 48 hours following TNBS treatment relative to healthy controls (N = 10). C) The epithelial layer is damaged in TNBS colitis, with i) increased trans-epithelial electrical resistance (R_TE), ii) decreased epithelial conductance, iii) decreased epithelial short-circuit current (I_SC), and iv) increased FITC-dextran translocation into serum. D) IL-1β concentrations are increased in TNBS colitis. (N = 4). Mean±SEM. *** P<0.001.