Estimates of T_SCM cell parameters from the implicit kinetic heterogeneity model.

<p>(A-H) Estimates of T_SCM cell parameters as a function of <i>k</i> in the CD4⁺ (top row: A—D) and CD8⁺ (bottom row: E—H) lineages. Isotope labelling and telomere length data were fitted simultaneously, fixing the clonal expansion size <i>k</i> to values between 0 and 20 and leaving the remaining parameters free. (A) and (E) show the variation in the sum of squared residuals (‘SSR’) with <i>k</i> in CD4⁺ and CD8⁺ T cells respectively; (B) and (F) show the variation in the fraction of newly generated T_SCM cells originating from self-renewing T_SCM proliferation computed as (<i>p</i>_<i>s</i>T_SCM) / (2^kΔT_N + <i>p</i>_<i>s</i>T_SCM); (C) and (G) show the variation in T_SCM half-lives for CD4⁺ and CD8⁺ T cells, respectively, and (D) and (H) the variation in T_SCM antigen-specific precursor lifespans (time until the last cell specific for a given antigen dies or differentiates). In all cases, <i>k</i> is plotted on the <i>x</i> axis. All results depicted are provided in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2005523#pbio.2005523.s010" target="_blank">S1 Data</a>. T_SCM, stem cell–like memory T.