Haplotypes of <i>TNF-α</i> polymorphisms and the risk for hospital admission and death of severe fever with thrombocytopenia syndrome (SFTS).

<p>(A) Genomic structure of the <i>TNF-α</i> locus and five polymorphic sites used. Exons (boxes) and introns are not drawn to scale; open boxes represent noncoding sequences, filled boxes represent coding sequences. (B) Linkage disequilibrium (LD) map of SNPs based on the <i>D</i>´. (C) LD map of SNPs based on <i>r</i>². (D) Global <i>P</i> values from single-locus and multilocus (two to five) association analysis and haplotypes with significant association between hospitalized SFTS patients and asymptomatic/mild SFTSV-infected subjects. (E) Global <i>P</i> values from single-locus and multilocus association analysis and haplotypes with significant association for hospital admission of SFTS. (F) Global <i>P</i> values from single-locus and multilocus (two to five) association analysis and haplotypes with significant association between non-fatal and fatal SFTS patients. (G) Global <i>P</i> values from single-locus and multilocus association analysis and haplotypes with significant association for death of SFTS.