Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Additional file 5: of Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimerâs disease

Sunil Adav (3485534)
Jung Park (2351599)
Siu Sze (3476045)

January 2019

Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and ...

Additional file 5: of Glycoprotein NMB: a novel Alzheimerâs disease associated marker expressed in a subset of activated microglia

Melanie HĂźttenrauch (5875208)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Correlation analysis between GPNMB-ELISA (TBS- and SDS-soluble fractions) and GPNMB expression level...

Additional file 5: of Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah Rothman (5725808)
Keith Tanis (5320037)
Pallavi Gandhi (5725811)
Vladislav Malkov (116467)
Jacob Marcus (250335)
Michelle Pearson (5071643)
Richard Stevens (715814)
Jason Gilliland (92030)
Christopher Ware (589212)
Veeravan Mahadomrongkul (4034981)
Elaine O’Loughlin (5725814)
Gonzalo Zeballos (5725817)
Roger Smith (10569)
Bonnie Howell (1801831)
Joel Klappenbach (4640113)
Matthew Kennedy (17789)
Christian Mirescu (3839689)

September 2018

Figure S3. Tg2576 brain sections illustrating amyloid-beta pathology. Representative images of plaqu...

Additional file 4: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S3. GO Elite analysis of differentially expressed proteins in WT, LPS-treated WT and 5xFAD mou...

Additional file 1: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S1. Log2 transformed protein abundance data and differential expression analyses. (XLSX 1522 k...

Additional file 2: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S2. GO Elite analysis of all 4,133 proteins identified in mouse microglia by TMT mass spectrom...

Additional file 3: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Supplemental Figures. Figure S1. Hierarchical clustering of proteins differentially expressed (p<0.0...

Additional file 1: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimerâs disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S1. Mouse microglial transcriptomic modules identified by Weighted Correlation Network Analysi...

Additional file 5: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S5. Enrichment analysis of GWAS-identified human AD-risk genes in mouse microglial modules. (X...

Additional file 3: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S3. Identification of potential transcriptional regulators of mouse microglial modules. (XLSX ...

Additional file 3: of Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimerâs disease

Qi Zhang (28502)
Cheng Ma (298689)
Marla Gearing (1939525)
Peng Wang (34436)
Lih-Shen Chin (62183)
Lian Li (49049)

March 2018

Table S3. List of novel proteins with altered abundances in AD identified in the present study. The ...

Additional file 4: of Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Melanie Hüttenrauch (5875202)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Immunostaining against Aβ and GPNMB in parallel sections in the cortex of a 12-month-old APP23 mouse...

Additional file 3: of Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Melanie Hüttenrauch (5875202)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Quantification of Aβ plaque load and GPNMB immunoreactivity in 5XFAD mice. (PDF 434 kb

Additional file 2: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S2. Gene Ontology (GO) analyses of Blue, Magenta, Yellow and Midnightblue mouse microglial mod...

Additional file 8: of Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah Rothman (5725808)
Keith Tanis (5320037)
Pallavi Gandhi (5725811)
Vladislav Malkov (116467)
Jacob Marcus (250335)
Michelle Pearson (5071643)
Richard Stevens (715814)
Jason Gilliland (92030)
Christopher Ware (589212)
Veeravan Mahadomrongkul (4034981)
Elaine O’Loughlin (5725814)
Gonzalo Zeballos (5725817)
Roger Smith (10569)
Bonnie Howell (1801831)
Joel Klappenbach (4640113)
Matthew Kennedy (17789)
Christian Mirescu (3839689)

September 2018

Figure S4. Expression of microglial versus peripheral macrophage markers. Data were analyzed for fol...

Additional file 5: of Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimerâs disease

Sunil Adav (3485534)
Jung Park (2351599)
Siu Sze (3476045)

January 2019

Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and ...

Additional file 5: of Glycoprotein NMB: a novel Alzheimerâs disease associated marker expressed in a subset of activated microglia

Melanie HĂźttenrauch (5875208)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Correlation analysis between GPNMB-ELISA (TBS- and SDS-soluble fractions) and GPNMB expression level...

Additional file 5: of Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah Rothman (5725808)
Keith Tanis (5320037)
Pallavi Gandhi (5725811)
Vladislav Malkov (116467)
Jacob Marcus (250335)
Michelle Pearson (5071643)
Richard Stevens (715814)
Jason Gilliland (92030)
Christopher Ware (589212)
Veeravan Mahadomrongkul (4034981)
Elaine O’Loughlin (5725814)
Gonzalo Zeballos (5725817)
Roger Smith (10569)
Bonnie Howell (1801831)
Joel Klappenbach (4640113)
Matthew Kennedy (17789)
Christian Mirescu (3839689)

September 2018

Figure S3. Tg2576 brain sections illustrating amyloid-beta pathology. Representative images of plaqu...

Additional file 4: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S3. GO Elite analysis of differentially expressed proteins in WT, LPS-treated WT and 5xFAD mou...

Additional file 1: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S1. Log2 transformed protein abundance data and differential expression analyses. (XLSX 1522 k...

Additional file 2: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Table S2. GO Elite analysis of all 4,133 proteins identified in mouse microglia by TMT mass spectrom...

Additional file 3: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Ali Raza (4905754)
Tianwen Gao (262800)
Hailian Xiao (36120)
Ranjita Betarbet (4174207)
Duc Duong (4174198)
James Webster (3633883)
Chadwick Hales (3491627)
James Lah (3504050)
Allan Levey (3504062)
Nicholas Seyfried (3504065)

June 2018

Supplemental Figures. Figure S1. Hierarchical clustering of proteins differentially expressed (p<0.0...

Additional file 1: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimerâs disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S1. Mouse microglial transcriptomic modules identified by Weighted Correlation Network Analysi...

Additional file 5: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S5. Enrichment analysis of GWAS-identified human AD-risk genes in mouse microglial modules. (X...

Additional file 3: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S3. Identification of potential transcriptional regulators of mouse microglial modules. (XLSX ...

Additional file 3: of Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimerâs disease

Qi Zhang (28502)
Cheng Ma (298689)
Marla Gearing (1939525)
Peng Wang (34436)
Lih-Shen Chin (62183)
Lian Li (49049)

March 2018

Table S3. List of novel proteins with altered abundances in AD identified in the present study. The ...

Additional file 4: of Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Melanie Hüttenrauch (5875202)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Immunostaining against Aβ and GPNMB in parallel sections in the cortex of a 12-month-old APP23 mouse...

Additional file 3: of Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

Melanie Hüttenrauch (5875202)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Quantification of Aβ plaque load and GPNMB immunoreactivity in 5XFAD mice. (PDF 434 kb

Additional file 2: of Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

Srikant Rangaraju (4174204)
Eric Dammer (4174213)
Syed Raza (4174210)
Priyadharshini Rathakrishnan (5245535)
Hailian Xiao (36120)
Tianwen Gao (262800)
Duc Duong (4174198)
Michael Pennington (1343655)
James Lah (3504050)
Nicholas Seyfried (3504065)
Allan Levey (3504062)

May 2018

Table S2. Gene Ontology (GO) analyses of Blue, Magenta, Yellow and Midnightblue mouse microglial mod...

Additional file 8: of Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah Rothman (5725808)
Keith Tanis (5320037)
Pallavi Gandhi (5725811)
Vladislav Malkov (116467)
Jacob Marcus (250335)
Michelle Pearson (5071643)
Richard Stevens (715814)
Jason Gilliland (92030)
Christopher Ware (589212)
Veeravan Mahadomrongkul (4034981)
Elaine O’Loughlin (5725814)
Gonzalo Zeballos (5725817)
Roger Smith (10569)
Bonnie Howell (1801831)
Joel Klappenbach (4640113)
Matthew Kennedy (17789)
Christian Mirescu (3839689)

September 2018

Figure S4. Expression of microglial versus peripheral macrophage markers. Data were analyzed for fol...

Additional file 5: of Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimerâs disease

Sunil Adav (3485534)
Jung Park (2351599)
Siu Sze (3476045)

January 2019

Figure S1. Quantitative abundances of the proteins involved in mitochondrial fusion and fission and ...

Additional file 5: of Glycoprotein NMB: a novel Alzheimerâs disease associated marker expressed in a subset of activated microglia

Melanie HĂźttenrauch (5875208)
Isabella Ogorek (528694)
Hans Klafki (1735903)
Markus Otto (120832)
Christine Stadelmann (137943)
Sascha Weggen (185102)
Jens Wiltfang (44073)
Oliver Wirths (3554801)

October 2018

Correlation analysis between GPNMB-ELISA (TBS- and SDS-soluble fractions) and GPNMB expression level...

Additional file 5: of Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Sarah Rothman (5725808)
Keith Tanis (5320037)
Pallavi Gandhi (5725811)
Vladislav Malkov (116467)
Jacob Marcus (250335)
Michelle Pearson (5071643)
Richard Stevens (715814)
Jason Gilliland (92030)
Christopher Ware (589212)
Veeravan Mahadomrongkul (4034981)
Elaine O’Loughlin (5725814)
Gonzalo Zeballos (5725817)
Roger Smith (10569)
Bonnie Howell (1801831)
Joel Klappenbach (4640113)
Matthew Kennedy (17789)
Christian Mirescu (3839689)

September 2018

Figure S3. Tg2576 brain sections illustrating amyloid-beta pathology. Representative images of plaqu...

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Abstract

Extracted data

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Abstract

Extracted data

Related items

Related items

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Abstract

Extracted data

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Abstract

Extracted data

Related items

Related items

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins

Additional file 5: of Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimerâs disease-related proteins