Abundance of miR-210 in CCA tumor tissues was associated with a poor prognosis.

<p>(A) The expression of miR-210 was determined in CCA tumor tissues (n = 38) compared to adjacent non-tumorous tissues (n = 30) or normal bile duct (NBD) (n = 5). Data were normalized with U6 snRNA. A Mann–Whitney <i>U</i>-test showed that miR-210 was significantly increased in tumor tissues compared with adjacent non-tumorous tissues (<i>P</i> < 0.001) and normal bile ducts (NBD) (<i>P</i> < 0.001). (B) Kaplan-Meier curves of overall survival in CCA patients showed that patients with high miR-210 expression levels (dense line; n = 16) had significantly lower survival rates than those with low miR-210 expression levels (dotted line; n = 22; <i>P</i> = 0.009).