Gold-Catalyzed Post-Ugi Ipso-Cyclization with Switchable Diastereoselectivity
- Anton A. Nechaev (5505041)
- Kristof Van Hecke (1574854)
- Manzoor Zaman (5505044)
- Stepan Kashtanov (2391556)
- Liviu Ungur (1302318)
- Olga P. Pereshivko (1574860)
- Vsevolod A. Peshkov (1398691)
- Erik V. Van der Eycken (1574857)
Publication date
July 2018
DOIAbstract
A gold-catalyzed post-Ugi ipso-cyclization for the diastereoselective synthesis of spirocyclic pyrrol-2-one-dienone system is described. Tuning the catalytic system, solvent, and temperature allowed selectively attaining two sets of diastereoisomers. The scope of the process has been evaluated, and a putative mechanistic model was proposed
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