Genetic analysis of study group.

<p>(a) Selected genes upregulated in high PET intensity tumors (fold-change high vs. low >2, p<0.05). (b) Kaplan-Meier survivor curve representing overall survival (in months) for patients with high PET-intensity tumors (N = 11), medium intensity tumors (N = 13), and low intensity tumors (N = 10). (c) The most significantly enriched genes in PET-high tumors (p<0.05, fold change>2.0) were interrogated by DAVID gene ontology pathway analysis [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0199970#pone.0199970.ref024" target="_blank">24</a>]. Significant functional groups are shown. P-values are quantified as log units. (d) Average rank-based GSEA results for MSigDB Hallmark pathways. (e) RNA levels of core glycolysis enzymes (red) versus all genes (gray) in PET high (y axis) versus low (x-axis) tumors. “Core” enzymes were labeled such according to the KEGG gene set database.