Additional file 3 of Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

: Figure S1. Effects of perturbations in model parameters fall into two groups. The activity parameter that affects the pathway activation steps upstream of the MAPK Hog1 (referred to as c_active in [21], top panel) affects both the proportion of cells that activate the pathway (right mode of distribution) as well as the maximum activity of the pathway (location of the right mode), such that as the parameter is reduced, fewer cells activate the pathway and those that do, do so to a lesser extent. The bottom panel shows that the four parameters that affect the slow transcriptional steps below Hog1 (referred to as c_tfon, c_hogon, c_remon, c_polon in [21]) affect the proportion of cells in the right mode, but not the location of the mode, so the distributions appear more bimodal. Each plot contains predictions of the model where the original parameter value has been permuted in the range from 0 to 50% of the original parameter value in increments of 5%. (TIF 736 kb