Supplemental figure 4. Molecular and ultrastructural analysis of pituitary phenotype between cystic and dense pituitary organoids

(a) RT-qPCR expression analysis of pituitary stem cell markers in -/iDTR (dense) and GHCre/iDTR (cystic) pituitary organoids (relative to expression of housekeeping genes set as 1). *, P<0.05. (b) RT-qPCR expression analysis of early pituitary markers in dense and cystic pituitary organoids (relative to expression in control AP set as 1 and indicated by dotted line). Bars represent mean ± SEM (n=3). *, P<0.05; **, P<0.01. (c) RT-qPCR expression analysis of pituitary hormones in dense and cystic pituitary organoids (relative to expression in control AP set as 106). Bars represent mean ± SEM (n=3). *, P<0.05; **, P