The NNS sucralose alters gut microbiota in mice.

<p>(A) <i>Alpha</i> diversity of gut microbiota for the diets used. (B) The abundances of the major phyla of gut microbiota after various diets. (C) Relative changes in abundance of major microbiota phyla in chow fed mice. (D) Relative changes in abundance of major microbiota phyla in HFD fed mice. (E) Relative changes in genus of <i>Clostridium</i> and <i>Bifidobacterium</i> in chow fed mice. (F) Relative changes in genus of <i>Clostridium</i> and <i>Bifidobacterium</i> in HFD fed mice. All data n = 8 mice per group represented mean ± S.E.M., Two-way analysis of variance (ANOVA) with Bonferroni’s test for multiple comparisons was used. * p <0.05, n.s., not significant.