Additional file 2: of Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China

Pedigrees, sequencing chromatograms of disease-causing gene related to HSP families in our cohort. Figure S1. Pedigree, sequencing chromatograms of SPAST gene detected in 16 SPG4 families in our cohort. Figure S2. Western blot analysis of novel mutations of SPAST gene in HEK 293T cells. Figure S3. Pedigree, sequencing chromatograms of 6 ADHSP families in our cohort. Figure S4. Pedigree, sequencing chromatograms of CYP7B1 gene detected in 16 unrelated SPG5 families in our cohort. Figure S5. Pedigree, sequencing chromatograms of 5 ARHSP families in our cohort. (DOCX 9157 kb