<p>All cells in the model (A) express the same level of uPAR (the uPAR concentration in the cells is indicated by the red color) at initialization of a simulation. Local changes in fibrin-cell contact can increase local plasmin concentration (B), resulting in degradation of fibrin and release of active TGF<i>β</i>1 (C). TGF<i>β</i>1 can stimulate uPAR expression (D). The positive feedback loop selects ‘uPAR-rich’ cells in the monolayer (E), with a few cells having high level (red color) and most cells having low levels (blue color).</p
<p><b>A:</b> HEK-293 cells were seeded on glass coverslips and transiently transfected with EGFP-uPA...
The study of the mechanisms of development and progression of fibrosis is one of the key directions ...
Transforming growth factor-β1 (TGF-β1) plays important roles in diverse cellular programs and extrac...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
<div><p>In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary sca...
The plasminogen activation system, i.e., the fibrinolytic system, is one of the major plasma proteol...
of binding uPA and may be involved in regulating cell-associated plasminogen activation and pericell...
The mechanisms of BM hematopoietic stem/progenitor cell (HSPC) adhesion, engraftment, and mobilizati...
AbstractPlasmin (PLS) and urokinase-type plasminogen activator (UPA) are ubiquitous proteases that r...
<p>Plasminogen (PLG) reversibly binds fibrin, forming fibrin-bound plasminogen (<i>F</i><sub>PLG</su...
To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer-oligomer e...
activator (uPA) to its receptor (uPAR) on cell surfaces has the potential to influence degradation o...
To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer-oligomer e...
<p><b>A:</b> HEK-293 cells were seeded on glass coverslips and transiently transfected with EGFP-uPA...
The study of the mechanisms of development and progression of fibrosis is one of the key directions ...
Transforming growth factor-β1 (TGF-β1) plays important roles in diverse cellular programs and extrac...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold fo...
<div><p>In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary sca...
The plasminogen activation system, i.e., the fibrinolytic system, is one of the major plasma proteol...
of binding uPA and may be involved in regulating cell-associated plasminogen activation and pericell...
The mechanisms of BM hematopoietic stem/progenitor cell (HSPC) adhesion, engraftment, and mobilizati...
AbstractPlasmin (PLS) and urokinase-type plasminogen activator (UPA) are ubiquitous proteases that r...
<p>Plasminogen (PLG) reversibly binds fibrin, forming fibrin-bound plasminogen (<i>F</i><sub>PLG</su...
To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer-oligomer e...
activator (uPA) to its receptor (uPAR) on cell surfaces has the potential to influence degradation o...
To search for functional links between glycosylphosphatidylinositol (GPI) protein monomer-oligomer e...
<p><b>A:</b> HEK-293 cells were seeded on glass coverslips and transiently transfected with EGFP-uPA...
The study of the mechanisms of development and progression of fibrosis is one of the key directions ...
Transforming growth factor-β1 (TGF-β1) plays important roles in diverse cellular programs and extrac...