MOESM2 of Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Additional file 2: Figure S2. (A) RT-PCR showing XBP1-u and XBP1-s expression levels in DMSO, tunicamycin, sunitinib and sunitinib+chloroquine treated Panc3.27 cells. Sunitinib or sunitinib+chloroquine treatment does not alter the expression of XBP1-s. (B) Histological analysis of mice treated with chemotherapeutics, sunitinib and chloroquine. The dual combination of Chemo+chloroquine, Chemo+sunitinib and the triple treatment of Chemo+sunitinib+gemcitabine shows noticeable reduction of ductal carcinoma (arrow). Scale bar: 10 ¾m. Sham vehicle control, Chemo gemcitabine plus paclitaxel, Sun sunitinib, CQ chloroquine