Evaluation of the extent of NMDA lesions.

<p>(A-A”) Schematic representation of three coronal sections encompassing the rostral, median and caudal parts of target structures (Reuniens and Rhomboid nuclei). Coordinates are given in mm from bregma, according to Paxinos and Watson, 2007. Abbreviations: AM, anteromedial thalamic nucleus; AMV, anteromedial thalamic nucleus, ventral part; CM, central medial thalamic nucleus; IAM, interanteromedial thalamic nucleus; ic, internal capsule; IMD, intermediodorsal thalamic nucleus; MDC, central mediodorsal thalamic nucleus; MDL, lateral mediodorsal thalamic nucleus; MDM, medial mediodorsal thalamic nucleus; mt, mammillothalamic tract; Paxi, paraxiphoid nucleus of thalamus; PC, paracentral thalamic nucleus; PHD, posterior hypothalamic area, dorsal part; Po, posterior thalamic nuclear group; PVA, anterior paraventricular thalamic nucleus; PVP, posterior paraventricular thalamic nucleus; Re, reuniens nucleus; Rh, rhomboid nucleus; Rt, reticular thalamic nucleus; Sub, submedius thalamic nucleus; VA, ventral anterior thalamic nucleus; VL, ventrolateral thalamic nucleus; VM, ventromedial thalamic nucleus; VPL, ventral posterolateral thalamic nucleus; VRe, ventral reuniens thalamic nucleus. (B-B”) and (C-C”), typical examples of NeuN immunostained and Cresyl violet stained adjacent brain sections of the same sham animal. (D-D”) and (E-E”), typical examples of NeuN immunostained and Cresyl violet stained adjacent brain sections of the same NMDA animal. Note the clear delimitation of the lesion area when using NeuN immunostaining.