Immunosuppressive drug therapy effects on NFATc1 amplification in T cell subsets.

<p>(A) NFATc1 amplification in CD4⁺CD28⁺, CD8⁺CD28⁺ and CD8⁺CD28^- T cells before transplantation (n = 21 kidney transplant patients). (B, C, D) Inhibition of NFATc1 amplification (MFI) after a TAC-(<i>grey</i>) or BELA-(<i>white</i>) based therapy. Delta NFATc1 expression (amplification) was determined at different time points after transplantation and compared to the samples before transplantation in CD4⁺CD28⁺ (B), CD8⁺CD28⁺ (C) and CD8⁺CD28^- T cells (D). The number of patients that were measured at each time point is shown on the x-axis in parentheses. n = 11 TAC-treated patients and n = 10 BELA-treated patients at day 0. Data are plotted as box and whiskers (Tukey style); *) p < 0.05, **) p < 0.01 compared to day 0.