SclB is an activator of asexual development and secondary metabolites in <i>A</i>. <i>nidulans</i>.

<p>A model depicting the regulatory roles of SclB in <i>A</i>. <i>nidulans</i> is presented. SclB activates conidiation through regulation of <i>brlA</i>, <i>flbC</i> and <i>flbD</i>. SclB is repressed by VosA and both factors support conidiospore viability. SclB acts as activator of secondary metabolites, such as emericellamides, austinol and dehydroaustinol, and fulfills parts of its functions in conjunction with RcoA. SclB acts as regulator of the oxidative stress response and activates gene expression of <i>catA</i>, <i>trxR</i> and <i>rsmA</i>, thereby regulating the oxidative stress response and secondary metabolism. Green arrows indicate positive, red lines negative regulations.