SclB regulates the oxidative stress response in <i>A</i>. <i>nidulans</i> in the presence of H₂O₂.

<p>A) Conidiospores of Δ<i>sclB</i>, Δ<i>vosA</i> and Δvos<i>A</i>Δ<i>sclB</i> strains show decreased survival in the presence of H₂O₂ compared to spores of wildtype (WT), <i>sclB</i> comp and <i>sclB</i> OE strains. Conidiospores were incubated with 100 mM H₂O₂ and approximately 200 spores plated at indicated time points. Error bars represent standard error of the mean of n ≥ 5 biological replicates (***<i>P</i><0.001). B) qRT-PCR indicates that expression of <i>trxR</i>, <i>catA</i>, <i>rsmA</i>, as well as <i>sclB</i> itself is induced upon H₂O₂ stress in WT and <i>sclB</i> OE but not in Δ<i>sclB</i>. Strains were grown vegetatively for 24 h and subsequently liquid cultures were incubated for 30 min with (grey boxes) or without (black boxes) 5 mM H₂O₂ (**<i>P</i><0.005, ***<i>P</i><0.001).