On peripheral proteins (‘Peripheral’ dataset) protrusions in low density regions are more often hydrophobes compared to the ‘Non-binding surfaces’.

<p>The plot shows the logarithm of the odds-ratio (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006325#pcbi.1006325.e026" target="_blank">Eq 10</a>) comparing the frequency of hydrophobes on ‘vertex residues’ in peripheral proteins and non-binding surfaces. Positive values reflect higher frequencies in the peripheral proteins. The horizontal axis shows the protein density <i>d</i> around the protrusion, measured as the number of C_α and C_β atoms within 1<i>nm</i>. Vertex residues are all on the convex hull, but only the vertex residues with <i>d</i> < 22 are protrusions. The leftmost bar with <i>d</i> < 7 corresponds mostly to chain terminals. More precisely, the vertical axis shows where <i>A</i> denotes the dataset ‘Peripheral’, <i>B</i> the ‘Non-binding surfaces’, <i>l</i> and <i>u</i> denote the lower and upper limits of the ranges given on the vertical axis, and <i>d</i> is the local protein density defined in ‘Materials and methods’. Error bars are 95% confidence intervals.