Comparison between the simulation and experiments in WT muscle fibers.

<p>The simulated [Ca²⁺]reached at steady state in the three compartments and the experimental data for 1, 5, 20 and 60 Hz in WT mouse fibers are compared with experimental values. The free model parameters are adjusted to fit the data at 60 Hz. [Ca²⁺] is reported in μM in cytosol or mitochondrion (black and red lines, respectively) or in mM for SR (blue line). Dotted lines: experimental data; continuous lines: model predictions.