Selection of L-asparaginase PEGylation sites.

<p>(A) L-Asparaginase tetramer with subunits highlighted with different colors, one active site is represented in red spheres, the pre-selected PEGylation positions in blue spheres, and the distances between mutated residues (A38C and T263C) are shown by black dotted lines. (B) L-Asparaginase dimer showing two active sites relatively buried (red spheres) in comparison with the PEGylations sites (blue spheres).