Inhibition of Ras-ERK-ETS signaling improves function in <i>Drosophila</i> models of mitochondrial disease and Parkinson’s.

<p>(A,B) Knock-down of Aop (3166R-1) suppresses the climbing (A) and wing inflation phenotype (B) caused by pan-neuronal knock-down of Surf1 with <i>nSyb-Gal4</i>. (C,D) Heterozygosity for <i>pnt</i> (<i>pnt</i>^<i>Δ88</i>) suppresses the climbing (C) and wing inflation phenotype (D) caused by knock-down of Surf1 with <i>nSyb-Gal4</i>. (E,F) Heterozygosity for <i>Ras85D</i> (<i>Ras85D</i>^{<i>ΔC40B</i>}) suppresses the climbing (E) and wing inflation phenotype (F) caused by knock-down of Surf1 with <i>nSyb-Gal4</i>. Controls are <i>nSyb-Gal4</i> hemizygotes. (G,H) Heterozygosity for <i>pnt</i> (G), or <i>Ras85D</i> (H) suppresses the climbing phenotype in <i>park</i>^<i>25</i> homozygous flies. Controls are <i>w</i>^<i>1118</i>. Data are represented as mean +/- SEM, *p≤0.05, **p≤0.01, ***p≤0.001. For wing inflation assays the numbers of flies counted for each genotype are shown in white.