Zigzag Ligands for Transversal Design in Reticular Chemistry: Unveiling New Structural Opportunities for Metal–Organic Frameworks

Herein we describe the topological influence of zigzag ligands in the assembly of Zr­(IV) metal–organic frameworks (MOFs). Through a transversal design strategy using reticular chemistry, we were able to synthesize a family of isoreticular Zr­(IV)-based MOFs exhibiting the <b>bcu</b>rather than the <b>fcu</b>topology. Our findings underscore the value of the transversal parameter in organic ligands for dictating MOF architectures