Male GDF15 knockout DIO mice had lower metabolic rate than wildtype mice.

<p>(A) Oxygen consumption of male DIO mice: continuous 3-d recording and average value of each light cycle. (B) RER of male DIO mice: continuous 3-d recording and average value of each light cycle. (C) Heat production of male DIO mice: continuous 3-d recording and average value of each light cycle. n = 6. CLAMS recorded data are shown as mean. Analyzed average values are shown as mean±SEM. *p<0.05 between WT and KO by unpaired t-test.