Additional file 6: of GPR120 is an important inflammatory regulator in the development of osteoarthritis

GPR120 agonist accelerates wound repair in a mouse skin defected model. (A) Representative images and quantitative assay of the wound area at 8 days post-wounding. The DHA-treated mice had the smallest wound area compared with the control mice. Two-way ANOVA, *p < 0.05. (B) H&E stained images showed that the mice treated by DHA had a thickened epithelium. The bottom figures are higher magnification views of the rectangle areas in the upper figures. Black arrow: epidermis; red arrow: hair follicle. Scale bar = 800 μm (top), 200 μm (bottom). (C) Quantitative and (D) immunohistochemical analysis of CD68-positive cells (brown) in the wound healing region. The result indicated that the number of macrophage marker (CD68)-positive cells in DHA-treated mice is downregulated significantly compared with the control mice. The bottom figures are higher magnification views of the rectangle areas in the upper figures. ***p < 0.001. Scale bar = 400 μm (top), 50 μm (bottom). (PDF 227 kb