A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates <i>ex vivo</i> tropism - Fig 7

<p><b>Viral infectivity of EV71-VP1</b>_{<b>97R167G</b>}<b>and EV71-VP1</b>_{<b>97L167E</b>}<b>in Vero cells (A) and of EV71-VP1</b>_{<b>97R167G</b>}<b>, EV71-VP1</b>_{<b>97L167E</b>}<b>and EV71-VP1</b>_{<b>97L/R167E/G</b>}<b>in neural cells (B) in the presence of increasing doses of ı-carrageenan.</b> The percent of infection was measured by an immunocytochemistry assay in Vero cells (A) and by RT-qPCR on cell lysate 1 dpi in neural cells (B) and expressed as the mean (±SEM) compared to non-treated viruses. (N = 2). **P<0.005. The frequency plots are shown on the right (see <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007190#ppat.1007190.g003" target="_blank">Fig 3</a> for details).