Additional file 1: of Evolutionary stability of topologically associating domains is associated with conserved gene regulation

Figure S1. Breakpoint identification accuracy as compared to gene synteny. Considered are adjacent pairs of human genes with one-to-one orthologs and intergenic distance below a size threshold. (A) Positive predicted value as the fraction of non-syntenic gene pairs with breakpoint from all considered gene pairs (syntenic and non-syntenic) with breakpoint. (B) False positive rate as the percent of syntenic gene pairs with breakpoint from the sum of syntenic pairs with breakpoint and non-syntenic gene pairs without breakpoint. (PDF 21 kb