Heatmaps showing the relative abundance of the 29 most abundant genera of each sample at pre-treatment (A) and post-treatment (B).

<p>Each column in the heatmap represents a specific sample and each row represents a genera. Colors represent the scaled relative abundance of genera with green and red representing low and high abundance, respectively. Samples and genera were clustered hierarchically (using the Ward method [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006620#pntd.0006620.ref038" target="_blank">38</a>]) based on Euclidean distance of the relative abundance profiles and were depicted on the top and left dendrogram, respectively. The infection status, treatment allocation, Shannon and richness indices for all samples were annotated above the heatmap. Circles in Shannon and richness represents the diversity indices for each sample. There is no clustering of samples or genera based on infection or treatment status.