People with Type 1 Diabetes and Increased Hypoglycemia Frequency have a Higher Risk for Nocturnal Hypoglycemia During the Second Half of the Night

Based on the baseline data of a multi-center randomized CGM trial (HypoDE), we analyzed the glucose recordings of participants with an increased hypoglycemia frequency. All 126 participants had type 1 diabetes and were on an MDI insulin therapy (age 46.5±11.5 yrs., 36.5% female, HbA1c 7.5±1.0%, hypoglycemia unawareness score 5.0±1.1). Each participant used a blinded CGM system (DexCom Gen 4) for 28 days. The percentage of glucose readings ≤70 mg/dl over a 24h period (6 am to 10 am; 10 am to 2 pm, 2 pm to 6 pm, 6 pm to 10 pm, 10 pm to 2 am, and 2 am to 6 am) were analyzed. During the whole day, on average 7.6% of all 288 glucose readings per patients were ≤70 mg/dl. From morning to evening, 192 of ≤70 mg/dl readings were between 7.0% and 7.3%. In the early night, this percentage was lower than during the late night, in which the percentage of ≤70 mg/dl values rose to >10% (p