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Turn-on and Turn-off Fluorescent Probes for Carbon Monoxide Detection and Blood Carboxyhemoglobin Determination

  • Shi, Genggongwo
  • Yoon, Taeseung
  • Cha, Seoncheol
  • Kim, Seulgi
  • Yousuf, Muhammad
  • Ahmed, Nisar
  • Kim, Doseok
  • Kang, Hyun-Wook
  • Kim, Kwang S.
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Publication date
June 2018
Icon DOI
10.1021/acssensors.8b00083
Publisher
American Chemical Society (ACS)
ISSN
2379-3694
Journal
ACS Sensors

Abstract

Water-soluble, carbazole-based two-photon excitable fluorescent probes MPVC-I ("turn-on") and MPVC-II ("turn-off") are rationally designed and synthesized for the selective monitoring of carbon monoxide (CO). Both probes can effectively measure carboxyhemoglobin (HbCO) in the blood of the animals exposed to a CO dose as low as 100 ppm for 10 min. The palladium catalyzed azidocarbonylation reaction was optimized to improve the sensing efficiency

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