DoctorThe regulation of translation is an important control mechanism in gene expression but is still not completely understood. However, it is becoming increasingly evident that the regulation of translation provides the cell with the plasticity that is needed to respond to rapid changes in the environment. Such regulation is very important under certain conditions - such as cellular stress (for example, heat shock, hypoxia, nutrient deprivation and ER stress) - that require immediate changes in protein levels. Translation of most mRNAs is suppressed under stress conditions. Phosphorylation of the a-subunit of eukaryotic translation initiation factor 2 (eIF2), which delivers initiator tRNA (Met-tRNAi) to the P site of the 40S ribosomal sub...
AbstractThe HCV internal ribosome entry site (IRES) directly regulates the assembly of translation i...
Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary ...
The HCV IRES binds to the translating ribosomes (Fig 1B). The Cap-dependent and HCV IRES-dependent ...
DoctorUnder various stress conditions, translations of most eukaryotic mRNAs are repressed. Inactiva...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Animal viruses have evolved a variety of strategies to ensure the efficient translation of their mRN...
The regulation of protein synthesis is critical in viral infection, cell death, and development. Mos...
Animal viruses have evolved a variety of strategies to ensure the efficient translation of their mRN...
DoctorEukaryotic cells have many strategies to control the translation of mRNA for the synthesis of ...
International audienceViruses depend on the host cell translation machinery for their replication, a...
Regulated loading of eIF3-bound 40S ribosomes on capped mRNA is generally dependent upon the transla...
The initiation of protein synthesis plays an essential regulatory role in human biology. At the cent...
The initiation of protein synthesis plays an essential regulatory role in human biology. At the cent...
AbstractThe HCV internal ribosome entry site (IRES) directly regulates the assembly of translation i...
Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary ...
The HCV IRES binds to the translating ribosomes (Fig 1B). The Cap-dependent and HCV IRES-dependent ...
DoctorUnder various stress conditions, translations of most eukaryotic mRNAs are repressed. Inactiva...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Chronic hepatitis C is often associated with oxidative stress. Hepatitis C virus (HCV) utilizes an i...
Animal viruses have evolved a variety of strategies to ensure the efficient translation of their mRN...
The regulation of protein synthesis is critical in viral infection, cell death, and development. Mos...
Animal viruses have evolved a variety of strategies to ensure the efficient translation of their mRN...
DoctorEukaryotic cells have many strategies to control the translation of mRNA for the synthesis of ...
International audienceViruses depend on the host cell translation machinery for their replication, a...
Regulated loading of eIF3-bound 40S ribosomes on capped mRNA is generally dependent upon the transla...
The initiation of protein synthesis plays an essential regulatory role in human biology. At the cent...
The initiation of protein synthesis plays an essential regulatory role in human biology. At the cent...
AbstractThe HCV internal ribosome entry site (IRES) directly regulates the assembly of translation i...
Unlike prokaryotes, a specialized eukaryotic initiation factor 2 (eIF2), in the form of the ternary ...
The HCV IRES binds to the translating ribosomes (Fig 1B). The Cap-dependent and HCV IRES-dependent ...