International audienceContext. NGC 253 is one of only two starburst galaxies found to emit γ-rays from hundreds of MeV to multi-TeV energies. Accurate measurements of the very-high-energy (VHE; E > 100 GeV) and high-energy (HE; E > 60 MeV) spectra are crucial to study the underlying particle accelerators, probe the dominant emission mechanism(s) and to study cosmic-ray interaction and transport.Aims. The measurement of the VHE γ-ray emission of NGC 253 published in 2012 by H.E.S.S. was limited by large systematic uncertainties. Here, the most up to date measurement of the γ-ray spectrum of NGC 253 is investigated in both HE and VHE γ-rays. Assuming a hadronic origin of the γ-ray emission, the measurement uncertainties are propagated into th...