Entrepreneurship scholars are increasingly interested in conducting work at the interface of design and science. However, a consistent methodological framework for this type of work is missing. In this paper, we therefore develop such a framework. First, three examples of entrepreneurship scholarship at the design-science interface are outlined. From these examples, we infer two key characteristics of design science (DS). For one, research outputs not only include theoretical constructs and models, but also values, principles and practices. In addition, creative design and scientific validation are complementary and equivalent research activities in DS. Whereas design and validation are legitimate research approaches in their own right, we ...