This thesis is breathing new life into the location choice models of establishments. The need for methodological advances in order to more realistically model the complexity of establishment decision-making processes, such as their optimal location choices, is the key motivation of this thesis. First, location choice models use geo-referenced data, for which choice sets have an explicit spatial component. It is thus critical to understand how to represent spatial aspect in location choice models. The final decision of an establishment seems to be related to the surrounding economic landscape. When accounting for the linkage between neighboring observations, the decision on the spatial weight matrix specification must be made. Yet, researche...