LINE-1 (L1) is a non-long terminal repeat (LTR) retrotransposon inserted throughout the human genome. APOBEC3 (A3) proteins are part of a network of host intrinsic defenses capable of restricting retroviruses and the replication of L1 retroelements. These enzymes inactivate retroviruses primarily through deamination of single-stranded viral DNA. In contrast, only A3A deaminates L1 DNA, while the other six A3 proteins restrict L1 to varying degrees through yet poorly defined mechanisms. Here we provide further insight into the molecular attributes of L1 restriction by A3 proteins. We specifically investigated the roles of A3 protein oligomerization, interactions with RNA and their binding to the various L1 proteins. Our results show that com...
While the ability of APOBEC3G to reduce the replica-tion of a range of exogenous retroviruses is now...
The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutiona...
APOBEC3G (A3G) is a host-encoded protein that potently restricts the infectivity of a broad range of...
Human APOBEC3 proteins are host-encoded intrinsic restriction factors that can prevent the replicati...
Approximately 17 % of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, ...
The human cytidine deaminase APOBEC3G (A3G) and other APOBEC3 proteins exhibit differential inhib-it...
<div><p><i>Alu</i> and LINE-1 (L1), which constitute ~11% and ~17% of the human genome, respectively...
Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in hum...
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retr...
Approximately 17 % of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, ...
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the replicat...
Protein-coding genes account for ~3% of the human genome, and a typical gene resides permanently at ...
APOBEC3 proteins are important for antiretroviral defense in mammals. The activity of these factors ...
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retr...
While the ability of APOBEC3G to reduce the replica-tion of a range of exogenous retroviruses is now...
While the ability of APOBEC3G to reduce the replica-tion of a range of exogenous retroviruses is now...
The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutiona...
APOBEC3G (A3G) is a host-encoded protein that potently restricts the infectivity of a broad range of...
Human APOBEC3 proteins are host-encoded intrinsic restriction factors that can prevent the replicati...
Approximately 17 % of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, ...
The human cytidine deaminase APOBEC3G (A3G) and other APOBEC3 proteins exhibit differential inhib-it...
<div><p><i>Alu</i> and LINE-1 (L1), which constitute ~11% and ~17% of the human genome, respectively...
Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in hum...
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retr...
Approximately 17 % of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, ...
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the replicat...
Protein-coding genes account for ~3% of the human genome, and a typical gene resides permanently at ...
APOBEC3 proteins are important for antiretroviral defense in mammals. The activity of these factors ...
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retr...
While the ability of APOBEC3G to reduce the replica-tion of a range of exogenous retroviruses is now...
While the ability of APOBEC3G to reduce the replica-tion of a range of exogenous retroviruses is now...
The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutiona...
APOBEC3G (A3G) is a host-encoded protein that potently restricts the infectivity of a broad range of...